Short Curriculum Vitae
PERSONAL DETAILS
Name: Professor Charles Vyvyan HOWARD
Address: Centre for Molecular Biosciences
University of Ulster
Cromore Road
Coleraine, BT52 1SA
FURTHER/HIGHER EDUCATION
Education: 1965-70 University of Liverpool: Faculty of Medicine. MB ChB
Qualifications: 1970 MB ChB, Liverpool
1983 Ph D, Liverpool in developmental neurobiology
1995 MRCPath
1999 FRCPath
WORK EXPERIENCE
2005 - Professor of Bioimaging, University of Ulster 1991 – 2005 Senior Lecturer in Anatomy, University of Liverpool
1975 - 1991 Lecturer in Anatomy, University of Liverpool
1971 - 1975 Demonstrator in Anatomy, University of Liverpool
MEMBERSIP OF PROFESSIONAL BODIES
Fellow: - Royal College of Pathologists
RESEARCH INTERESTS
Vyvyan Howard is a medically qualified pathologist with interests in low dose minimal
change toxicology, particularly of the nervous system. He has worked for many years in the field of developmental neurotoxicology, including the actions of pharmaceutical agents, pesticides and environmental pollutants. He is an expert on the quantification of toxicological change with the use of stereology. He is involved in the development of new technical innovations such as the atom force microscope that allows scanning of live cells under physiological conditions, and the novel ion-beam cryo microscopy that permits the analysis of minute alterations in the anatomy of neurons and dendritic trees.
CURRENT FUNDING
2006 – 2008 £250,000 STREP project ‘Nanointeract’ under EU Framework 6. Part of a € 3.3 million multicentre study on the fate and toxicity of engineered nanoparticles
2005 -2007 £140,000 project to investigate the chronic toxicity of NMDA antagonists in monkey and rat brain. Funded by AstraZeneca plc.
Honours:
1989 - Awarded Royal Microscopical Society 150th Anniversary Gold Medal for services to microscopy.
1999 - Overall Winner, Caroline Walker Trust 11th Annual Awards for improving public health through food.
Recent Publications
[102] Axelrad JC, Howard CV, McLean WG. (2003).
‘The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon’ Toxicology 185: 67-78.
[103] Hill A, Howard CV, Strahle U, Cossins A (2003).
‘Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations.’ Toxicological Sciences 76: 392-399.
[104] Howard CV, de Yanes GS (2003)
'Telomere length and mortality' Lancet 361: 1224
[105] Pennycook FR, Diamand EM, Watterson A, Howard CV.(2004).
Modeling the Dietary Pesticide Exposures of Young Children. International Journal of Occupational and Environmental Health 10: 304-309.
[106] Stott A, Nik H, Platt MJ, Casson IF, Walkisnshaw, Howard V, Stanisstreet M, Pennycook S.(2004).
Glycaemic control in pregnant women with type 1 diabetes and fetal macrosomia. Practical Diabetes International 21: 209-240.
[107] Cranston A, Howard L, Howard CV (2004).
Quantitative phenotyping as an efficient means to estimate C-cell number in a knock-in mouse model of MEN2B. Transgenic Research, 13: 339-348.
[108] Newby J & Howard C.V. (2005). Environmental influences in cancer aetiology.J. Nutr. And Envir. Med. 15: 56-114.
[109] Lau K, McLean WG, Williams DP, and Howard CV. (2006).
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicological Sciences.90: 178-187.
[110] Sneddon JC, Boomker E and Howasd CV (2006). Mucosall surface area and fermentation activity in the hind gut of hydrated and chronically dehydrated working donkeys. J. Anim. Sci. 84: 119-124.
[111] Ellis KA, Innocent G, Grove-White D, Cripps P, McLean WG, Howard CV, and Mihm M (2006). Comparing the fatty acid composition of organic and conventional milk. Journal of Dairy Science. 89: 1938-1950.
[112] E.M. Kannekens, R.D. Murray, C.V. Howard and J. Currie. (2006).
Stereological method for estimating feto-maternal exchange surface area in the
bovine placentome at 135 days gestation. Res. Vet. Sci.81: 120-127.
BOOKS
Unbiased Stereology. 1st Edition (Bios Scientific Publishers, Oxford UK, 1998, ISBN 1-85996-071-5) 246
Howard C V and Maynard R L (Author/Editors)
Particulate Matter: Properties and Effects upon Health. (Bios Scientific Publishers, Oxford UK, 1999, ISBN 1-85996-172-X) 184
Nicolopolou-Stamati P, Hens L and Howard C V (Author/Editors)
Health Impacts of Waste Management Policies. (Kluwer Academic Publishers, Dordrecht, The Netherlands, 2000, ISBN 0-7923-6362-0) 326
Nicolopolou-Stamati P, Hens L and Howard C V (Author/Editors)
Environmental Health Aspects of Endocrine Disruptors. (Kluwer Academic Publishers, Dordrecht, The Netherlands, 2001, ISBN 0-7923-7056-2) 376
Nicolopolou-Stamati P, Hens L, Howard C V and Van Larebeke N (Author/Editors)
Cancer as an Environmental Disease. (Kluwer Academic Publishers, Dordrecht, The Netherlands, 2004, ISBN 1-4020-2019-8) 236
Unbiased Stereology. 2nd Edition (Garland Bios Scientific Publishers, Abingdon UK, 2005, ISBN 1-8599-6089-8) 277.