1          Dr. Irvine G. Brent

2          DEGREES:
BSc  Biochemistry  1st class     Queen's University of Belfast 1972
PhD Biochemistry   Queen's University of Belfast 1977

3          CURRENT POST
Senior Lecturer
School of Medicine & Dentistry
The Queen's University of Belfast

4          LAST 3 POSTS HELD (with dates):
1980-2000 Department of Biochemistry, Queen's University Belfast, Lecturer
1979-1980 Department of Biochemistry, Queen's University Belfast, Research Assistant
1977-1978 Department of Clinical Biochemistry, Oxford University, Research Assistant

5. RECENT PUBLICATIONS

• Irvine,El-Agnaf, O.M.A., Guthrie, D.J.S., Walsh, D.M. and Irvine, G.B. (1998). The influence of the central (19-25) region on the aggregation properties and secondary structure of Alzheimer’s amyloid b-peptide. Eur. J. Biochem. 256, 560-569.
• El-Agnaf, O.M.A., Bodles, A.M., Guthrie, D.J.S., Harriott, P. and Irvine, G.B. (1998) The N-terminal region of non-Ab component of Alzheimer’s Disease amyloid is responsible for its tendency to assume b-sheet and aggregate to form fibrils. Eur. J. Biochem. 258, 157-163.
• El-Agnaf, O.M.A., Irvine, G.B., Fitzpatrick, G., Glass, K.W. and Guthrie, D.J.S. (1998) Comparative studies on peptides representing the so called tachykinin-like region of Alzheimer Ab peptide, Ab (25-35). Biochem. J. 336, 419-427.
• 5          Bodles, A.M., Guthrie, D.J.S., Greer, B. and Irvine, G.B. (2001) Identification of the region of non-Ab component of Alzheimer’s disease amyloid responsible for its aggregation and toxicity. J. Neurochem. 78, 384-395.
• Bodles, A.M., El-Agnaf, O.M.A., Greer, B., Guthrie, D.J.S., and Irvine, G.B. (2004) Inhibition of fibril formation and toxicity of a fragment of α-synuclein by an N-methylated peptide analogue. Neurosci. Letts. 359, 89-93.